CURRICULUM VITAE

 

 (October, 2008)

Takashi Ohtsuka, M.D., Ph.D.

 

Identical information

Sex: Male

  Citizenship: Japan

 

Educational history

March 1990        Graduated from Kaisei High school (Tokyo, Japan)

March 1996         M.D. Faculty of Medicine, Keio University (Tokyo, Japan)

  December 2006    Ph.D.  School of Medicine, Keio University (Tokyo, Japan)

 

 

License and certification

1996   Passed the Examination of Japanese National Board

2000   Certification, The Board of Japan Surgical Society

2002   Certification, The Board of Japanese Association for Thoracic Surgery

2004   Certification, The Board of Japanese Association for General Thoracic Surgery

2007   Passed USMLE step 1

2008   Passed USMLE Step 2 CK

2008   Passed USMLE Step 2 CS

2008   ECFMG certification

 

 

Professional background (employment history)

May 1996 – March 1997    Resident, Department of General Surgery, Keio University Hospital (Tokyo, Japan)

 

  May 1997 – April 1998        Resident, Department of General Surgery, Ogikubo Hospital (Tokyo, Japan)

 

  May 1998 – April 1999        Resident, Department of General Surgery, Saitama Hospital (Saitama, Japan)

 

  May 1999 – March 2002    Clinical Fellow, Department of General Thoracic Surgery, Keio University Hospital (Tokyo, Japan)

 

  May 2002 – May2006         Attending Surgeon, Department of Thoracic Surgery, Emperor Gifted Foundation Saiseikai Central Hospital, (Tokyo, Japan)

 

  June 2006 - present             Research Fellow, Internal Medicine – Cardiology, Cardiovascular Center, University of Michigan (Ann Arbor, MI, U.S.A.)

 

 

Awards, Honors and Scholarships

Sanshi-kai Award (educational scholarship from Keio University, Tokyo, Japan)

Title: Major pulmonary resection by VATS

Suzuken Memorial Foundation Award

Title: In vivo identification of sentinel lymph nodes for non-small cell lung cancer for abbreviation of mediastinal lymph node dissection

 

Grant

2000-2001      US$20.000

Grant-in-Aid for Young Scientists,

The ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan

Title: Analysis of angiogenic profiles by estimation of tumor blood flow with colored dye extraction microspheres after antiangiogenic therapy.

 

2002  US$10.000

Grant-in-Aid for Young Scientists,

The ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan

Title: Function of ADAM (a disintegrin and metalloproteinases) in non-small cell lung carcinomas.

 

Research Interest

Lung transplantation

Lung ischemia reperfusion injury

Lung cancer

Thoracoscopic surgery

 

Reviewer for following journals

 CHEST

 Lung Cancer

 BMC Cancer

 

Professional memberships

  Japan Surgical Society

  Japanese Association for Thoracic Surgery

  Japanese Association for Chest Surgery

  Japanese Society for Endoscopic Surgery

  Japan Lung Cancer Society

  Japanese Society for Bronchology

  American Thoracic Society

Publications

 

1.        Iwamaru A, Watanabe M, Yu S, Ohtsuka T, Horinouchi H, Kobayashi K.  Measurement of tumor blood flow using colored dye extraction microspheres in two rat tumor models.  Int J Oncol. 2001 ; 18 : 227-32. 

 

2.        Nomori H, Ohtsuka T, Horio H, Naruke T, Suemasu K.   Difference in the impairment of vital capacity and 6-minute walking after a lobectomy performed by thoracoscopic surgery, an anterior limited thoracotomy, an anteroaxillary thoracotomy, and a posterolateral thoracotomy.  Surg Today. 2003 ; 33 : 7-12.

 

3.        Nomori H, Ohtsuka T, Horio H, Naruke T, Suemasu K  Thoracoscopic lobectomy for lung cancer with a largely fused fissure.  Chest. 2003 ; 123 : 619-22. 

 

4.        Nomori H, Ootsuka T, Horio H, Naruke T, Suemasu K.  Bilateral internal thoracic artery injury induced by blunt trauma.  Jpn J Thorac Cardiovasc Surg. 2003 ; 51 : 214-6.

 

5.        Nomori H, Ohtsuka T, Naruke T, Suemasu K. Differentiating between atypical adenomatous hyperplasia and bronchioloalveolar carcinoma using the computed tomography number histogram.  Ann Thorac Surg. 2003 ; 76 : 867-71. 

 

6.        Iwamaru A, Watanabe M, Ohtsuka T, Horinouchi H, Kobayashi K.  Analysis of angiogenic profiles by estimation of tumor blood flow with colored dye extraction microspheres after antiangiogenic therapy.  Oncol Rep. 2003 ;10 :1127-31.

 

7.        Nomori H, Ohtsuka T, Naruke T, Suemasu K. Histogram analysis of computed tomography numbers of clinical T1 N0 M0 lung adenocarcinoma, with special reference to lymph node metastasis and tumor invasiveness.  J Thorac Cardiovasc Surg. 2003 ; 126 : 1584-9.

 

8.        Ohtsuka T, Nomori H, Horio H, Naruke T, Suemasu K. Radiological examination for peripheral lung cancers and benign nodules less than 10 mm.  Lung Cancer. 2003 ; 42 : 291-6.   

 

9.        Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K. Six-minute walking and pulmonary function test outcomes during the early period after lung cancer surgery with special reference to patients with chronic obstructive pulmonary disease. Jpn J Thorac Cardiovasc Surg. 2004 ; 52 : 113-9.

 

10.    Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Uno K.    The size of metastatic foci and lymph nodes yielding false-negative and false-positive lymph node staging with positron emission tomography in patients with lung cancer.  J Thorac Cardiovasc Surg. 2004 ; 127 : 1087-92.

 

11.    Ohtsuka T, Nomori H, Horio H, Ebihara A, Naruke T, Suemasu K.  Superior sulcus lung cancer invading the ribs and brachial plexus successfully resected by modified trap-door thoracotomy after induction chemoradiotherapy.  Jpn J Thorac Cardiovasc Surg. 2004 ; 52 : 181-4.

 

12.    Ohtsuka T, Nomori H, Horio H, Naruke T, Suemasu K.   Is major pulmonary resection by video-assisted thoracic surgery an adequate procedure in clinical stage I lung cancer?  Chest. 2004 ; 125 : 1742-6.

 

13.    Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Uno K.  Evaluation of F-18 fluorodeoxyglucose (FDG) PET scanning for pulmonary nodules less than 3 cm in diameter, with special reference to the CT images.  Lung Cancer. 2004 ; 45 : 19-27

 

14.    Ohtsuka T, Nomori H, Horio H, Naruke T, Suemasu K.  Reply to the editor.  Lung Cancer. 2004; 45 : 395-6.

 

15.    Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Kobayashi T, Uno K. Fluorine 18-tagged fluorodeoxyglucose positron emission tomographic scanning to predict lymph node metastasis, invasiveness, or both, in clinical T1 N0 M0 lung adenocarcinoma.  J Thorac Cardiovasc Surg. 2004 ; 128 : 396-401.

 

16.    Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K. In vivo identification of sentinel lymph nodes for clinical stage I non-small cell lung cancer for abbreviation of mediastinal lymph node dissection.  Lung Cancer. 2004 ; 46: 49-55.

 

17.    Kodama T, Ikeda E, Okada A, Ohtsuka T, Shimoda M, Shiomi T, Yoshida K, Nakada M, Ohuchi E, Okada Y. ADAM12 Is Selectively Overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. Am J Pathol. 2004 ; 165 :1743-53.

 

18.    Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Orikasa H, Yamazaki K. Pulmonary metastasis 12 years after resection of thymoma with microscopic capsule invasion. Jpn J Clin Oncol. 2004 ; 34 : 630-3.

 

19.    Horio H, Ohtsuka T, Kubota Y, Hasegawa T, Nomori H, Naruke T, Suemasu K. Large chest wall reconstruction using titanium micromesh and a pedicled latissimus dorsi musculocutaneous flap: report of a case. Surg Today. 2005 ; 35 : 73-75.

 

20.    Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Uno K. Visual and Semiquantitative Analyses for F-18 Fluorodeoxyglucose PET Scanning in Pulmonary Nodules 1 cm to 3 cm in Size. Ann Thorac Surg. 2005 ; 79 : 984-988.

 

21.    Nomori H, Imazu Y, Watanabe K, Ohtsuka T, Naruke T, Kobayashi T, Suemasu K. Radiofrequency ablation of pulmonary tumors and normal lung tissue in Swine and rabbits. Chest. 2005 ; 127 : 973-977.

 

22.    Ohtsuka T, Nomori H, Naruke T, Orikasa H, Yamazaki K, Suemasu K. Intrapulmonary schwannoma. Jpn J Thorac Cardiovasc Surg. 2005 ; 53 : 154-156.

 

23.    Ohtsuka T, Nomori H, Watanabe K, Naruke T, Orikasa H, Yamazaki K, Suemasu K, Uno K. False-positive Findings on [18F]FDG-PET Caused by Non-neoplastic Cellular Elements After Neoadjuvant Chemoradiotherapy for Non-small Cell Lung Cancer. Jpn J Clin Oncol. 2005 ; 35 : 271-3.

 

24.    Nomori H, Hirotani T, Watanabe K, Ohtsuka T, Naruke T, Suemasu K. Extended resection of lung cancer invading the left subclavian artery by using cardiopulmonary bypass. Ann Thorac Cardiovasc Surg. 2005 ; 11 : 211-3.

 

25.    Nomori H, Kosaka N, Watanabe K, Ohtsuka T, Naruke T, Kobayashi T, Uno K. 11C-acetate positron emission tomography imaging for lung adenocarcinoma 1 to 3 cm in size with ground-glass opacity images on computed tomography. Ann Thorac Surg. 2005;80(6):2020-5.

 

26.    Shiomi T, Inoki I, Kataoka F, Ohtsuka T, Hashimoto G, Nemori R, Okada Y. Pericellular activation of proMMP-7 (promatrilysin-1) through interaction with CD151. Lab Invest. 2005;85(12):1489-506.

 

27.    Nomori H, Kosaka N, Watanabe K, Ohtsuka T, Naruke T, Kobayashi T, Uno K. 11C-acetate positron emission tomography imaging for lung adenocarcinoma 1 to 3 cm in size with ground-glass opacity images on computed tomography. Ann Thorac Surg. 2005;80(6):2020-5.

 

28.    Ohtsuka T, Shiomi T, Shimoda M, Kodama T, Amour A, Murphy G, Ohuchi E, Kobayashi K, Okada Y. ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis. Int J Cancer. 2006;118(2):263-73.

 

29.    Ohtsuka T, Nomori H, Watanabe K, Naruke T, Suemasu K, Kosaka N, Uno K. Positive imaging of thymoma by 11C-acetate positron emission tomography. Ann Thorac Surg. 2006;81(3):1132-4.

 

30.    Ohtsuka T, Watanabe K, Kaji M, Naruke T, Suemasu K. A clinicopathological study of resected pulmonary nodules with focal pure ground-glass opacity. Eur J Cardiothorac Surg. 2006;30(1):160-3.

 

31.    Watanabe K, Nomori H, Ohtsuka T, Naruke T, Ebihara A, Orikasa H, Yamazaki K, Uno K, Kobayashi T, Goya T. [F-18]Fluorodeoxyglucose Positron Emission Tomography Can Predict Pathological Tumor Stage and Proliferative Activity Determined by Ki-67 in Clinical Stage IA Lung Adenocarcinomas. Jpn J Clin Oncol. 2006;36(7):403-9.

 

32.    Watanabe K, Nomori H, Ohtsuka T, Kaji M, Naruke T, Suemasu K. Usefulness and complications of computed tomography-guided lipiodol marking for fluoroscopy-assisted thoracoscopic resection of small pulmonary nodules: experience with 174 nodules. J Thorac Cardiovasc Surg. 2006;132(2):320-4.

 

33.    Ohtsuka T, Nomori H, Watanabe K, Kaji M, Naruke T, Suemasu K. Obstructive subglottic granuloma after removal of a minitracheostomy tube. Ann Thorac Cardiovasc Surg. 2006;12(4):265-6.

 

34.    Ohtsuka T, Nomori H, Watanabe K, Kaji M, Naruke T, Suemasu K, Uno K. Prognostic significance of [(18)F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma. Cancer. 2006 ;107(10):2468-73.

 

35.    Mitsui Y, Mochizuki S, Kodama T, Shimoda M, Ohtsuka T, Shiomi T, Chijiiwa M, Ikeda T, Kitajima M, Okada Y.  ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3. Cancer Res. 2006 ;66(20):9913-20

 

36.    Ohtsuka T, Nomori H, Watanabe K, Kaji M, Ebihara A, Naruke T, Suemasu K. Isolated unilateral absence of a pulmonary artery treated by pneumonectomy in an adult: report of a case. Surg Today. 2006;36(6):525-7.

 

37.    Ebihara A, Nomori H, Watanabe K, Ohtsuka T, Naruke T, Uno K, Kuwahira I, Eguchi K. Characteristics of advantages of positron emission tomography over computed tomography for N-staging in lung cancer patients. Jpn J Clin Oncol. 2006 ;36(11):694-8.

 

38.    Kaji M, Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Uno K. 11C-acetate and 18F-fluorodeoxyglucose positron emission tomography of pulmonary adenocarcinoma. Ann Thorac Surg. 2007 ;83(1):312-4.

 

39.    Harada H, Lama VN, Badri LN, Ohtsuka T, Petrovic-Djergovic D, Liao H, Yoshikawa Y, Iwanaga K, Lau CL, Pinsky DJ. Early growth response gene-1 promotes airway allograft rejection. Am J Physiol Lung Cell Mol Physiol. 2007;293(1):L124-30.

 

40.    Jarvinen L, Badri L, Wettlaufer S, Ohtsuka T, Standiford TJ, Toews GB, Pinsky DJ, Peters-Golden M, Lama VN. Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator. J Immunol. 2008 Sep 15;181(6):4389-96.

 

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